IGF-1 LR3

What is IGF-1 LR3?

IGF-1 LR3 is an engineered form of Insulin-Like Growth Factor-1 featuring:

• Arginine substitution at position 3 (Arg³)
• 13-amino-acid N-terminal extension

These modifications reduce affinity for IGF Binding Proteins, allowing extended receptor availability in research models.

Mechanism of Action

IGF-1 LR3 binds to the IGF-1 Receptor (IGF-1R) and activates signaling pathways involved in cellular growth and metabolism, including:

• PI3K/Akt
• mTOR
• MAPK/ERK

Researchers study these pathways for their roles in:

• Cell proliferation
• Protein synthesis
• Cellular differentiation
• Cell survival
• Glucose metabolism
• Tissue regeneration

Its reduced IGFBP binding makes IGF-1 LR3 valuable for investigating sustained receptor activation.

Research Summary

Preclinical studies have explored IGF-1 LR3 in:

• Cell culture
• Animal models
• Molecular biology

Research commonly focuses on:

• Skeletal muscle biology
• Tissue regeneration
• Stem cell research
• Cellular proliferation
• Protein synthesis
• Metabolic regulation
• Growth factor signaling

Human clinical research remains limited, and IGF-1 LR3 has not been approved for therapeutic use.

Research Applications

IGF-1 LR3 is commonly investigated in:

• Cellular growth
• Muscle cell biology
• Satellite cell activation
• Protein synthesis
• Regenerative medicine
• Stem cell differentiation
• Metabolic signaling
• Tissue engineering
• IGF-1 receptor signaling
• Growth hormone pathway research

Chemical Information

Specifications may vary between production batches.

Storage

Lyophilized Powder

• Store at 2–8°C short term.
• Store at −20°C long term.
• Protect from heat, moisture, and light.

After Reconstitution

• Refrigerate at 2–8°C.
• Avoid repeated freeze–thaw cycles.
• Use sterile laboratory handling procedures.

Certificate of Analysis (COA)

Each batch includes a Certificate of Analysis verifying:

• Product identity
• Lot number
• Manufacturing date
• HPLC purity
• Molecular weight (MS)
• Appearance
• Peptide content
• Quality control approval

(Attach batch-specific COA download.)

Frequently Asked Questions

Is IGF-1 LR3 for human use?
No. This product is supplied exclusively for laboratory research and is not intended for human or veterinary use.

How is IGF-1 LR3 different from IGF-1?
Structural modifications reduce binding to IGF Binding Proteins, allowing researchers to study prolonged receptor signaling.

Does every batch include a COA?
Yes. Every batch includes a Certificate of Analysis confirming identity, purity, and quality testing.

How should it be stored?
Store lyophilized material refrigerated or frozen. After reconstitution, refrigerate and avoid repeated freeze–thaw cycles.

Is IGF-1 LR3 FDA approved?
No. It is a research compound and has not been approved by the U.S. FDA for therapeutic use.

Related Products

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• BPC-157
• TB-500
• GHK-Cu
• Sermorelin
• Hexarelin

Research Use Disclaimer

This product is intended solely for laboratory research purposes. It is not intended for human consumption, veterinary use, diagnosis, treatment, cure, or prevention of any disease. Users are responsible for complying with all applicable laws, regulations, and institutional guidelines governing the handling and use of research materials.