MOTS-C

What is MOTS-c?

MOTS-c is a 16-amino-acid peptide encoded by the mitochondrial 12S ribosomal RNA gene. Unlike most signaling peptides derived from nuclear DNA, MOTS-c originates from mitochondrial DNA and acts as a signaling molecule between mitochondria and the cell nucleus. It is being studied for its potential role in metabolic regulation, cellular stress adaptation, and healthy aging.

Mechanism of Action

Preclinical research suggests MOTS-c may help regulate cellular energy balance by:

• Activating AMP-activated protein kinase (AMPK)
• Promoting metabolic flexibility
• Supporting glucose utilization
• Regulating mitochondria-to-nucleus signaling
• Influencing oxidative stress responses
• Supporting cellular stress adaptation
• Modulating inflammatory signaling

These mechanisms remain under investigation.

Research Summary

Laboratory and animal studies have explored MOTS-c’s involvement in:

• Energy metabolism
• Glucose homeostasis
• Insulin sensitivity
• Exercise physiology
• Skeletal muscle biology
• Mitochondrial function
• Cellular aging
• Oxidative stress
• Obesity-related metabolic pathways
• Age-related physiological changes

Although findings are promising, human clinical research remains limited, and MOTS-c has not been approved for therapeutic use.

Research Applications

MOTS-c is commonly investigated in studies involving:

• Mitochondrial signaling
• Metabolic regulation
• Healthy aging
• Cellular stress adaptation
• Exercise physiology
• Insulin signaling
• Skeletal muscle metabolism
• Obesity research
• Type 2 diabetes models
• Energy homeostasis
• Oxidative stress
• Longevity research

Chemical Information

Specifications may vary by manufacturing batch.

Storage

Lyophilized Powder

• Store at 2–8°C short term.
• Store at −20°C long term.
• Protect from light and moisture.
• Keep vial tightly sealed.

After Reconstitution

• Refrigerate at 2–8°C.
• Avoid repeated freeze–thaw cycles.
• Use sterile laboratory techniques.
• Follow validated storage procedures.

Certificate of Analysis (COA)

Each batch includes a COA verifying:

• Product identity
• Batch/Lot number
• Manufacturing date
• HPLC purity
• Molecular weight (MS)
• Appearance
• Peptide content
• Quality control approval
• Storage recommendations

Download the applicable batch COA.

Frequently Asked Questions

Is MOTS-c intended for human use?
No. It is supplied exclusively for laboratory research and is not intended for human or veterinary use.

What makes MOTS-c unique?
It is one of the few biologically active peptides encoded by mitochondrial DNA, making it an important subject in mitochondrial signaling research.

Does every batch include a COA?
Yes. Every batch is supplied with a Certificate of Analysis confirming identity, purity, and quality testing.

How should it be stored?
Store lyophilized material refrigerated or frozen. After reconstitution, refrigerate and avoid repeated freeze–thaw cycles.

Is MOTS-c FDA approved?
No. It is a research compound and has not been approved by the U.S. FDA for therapeutic use.

What research fields use MOTS-c?
Common areas include mitochondrial biology, metabolism, aging, exercise physiology, oxidative stress, cellular signaling, and energy regulation.

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Research Use Disclaimer

This product is intended solely for laboratory research purposes. It is not intended for human consumption, veterinary use, diagnosis, treatment, cure, or prevention of any disease. Users are responsible for complying with all applicable laws, regulations, and institutional guidelines governing the handling and use of research materials.